Trintellix (Vortioxetine)
€199.00 – €327.00
Description
Trintellix (Vortioxetine)
Trintellix (vortioxetine) is a multimodal serotonin modulator approved for major depressive disorder (MDD) in adults. Unlike traditional SSRIs/SNRIs, it combines serotonin reuptake inhibition with direct receptor activity, offering enhanced cognitive benefits and lower sexual dysfunction rates.Buy Trintellix (Vortioxetine) online
Key Features & Benefits
✔ Broad-Spectrum Serotonin Activity –
SERT inhibitor (like SSRIs).Buy Trintellix (Vortioxetine) online
5-HT1A agonist (boosts mood)
5-HT3 antagonist (reduces nausea, aids cognition)
✔ Cognitive Improvement – Shown to enhance processing speed, memory, and executive function in depression.
✔ Low Sexual Dysfunction – Fewer libido/orgasm issues vs. SSRIs.
✔ Weight-Neutral – No significant metabolic changes.
Dosage & Administration
Available Strengths: 5mg, 10mg, 20mg tablets.
Starting Dose: 10mg once daily (5mg for sensitive patients).
Max Dose: 20mg/day (efficacy plateau beyond this).
Take With/Without Food – No absorption issues.
Mechanism of Action
| Target | Effect | Clinical Impact |
|---|---|---|
| SERT Inhibition | ↑ Synaptic serotonin | Antidepressant effect |
| 5-HT1A Agonism | ↑ Serotonin tone long-term | Mood stabilization |
| 5-HT3 Antagonism | Blocks nausea/cognitive interference | Improves focus, reduces GI upset |
| 5-HT7 Antagonism | May regulate circadian rhythms | Potential sleep benefits |
Side Effects
⚠ Common (≥5%):
Nausea (30%, usually transient)
Headache, diarrhea (mild)
⚠ Rare but Serious:Serotonin syndrome (if combined with MAOIs/other serotonergics)
Bleeding risk (caution with NSAIDs/anticoagulants)
Contraindications
MAOI use (risk of hypertensive crisis – wait 14 days between).
Strong CYP2D6 inhibitors (e.g., fluoxetine, quinidine – may ↑ vortioxetine levels).
Comparison to Other Antidepressants
| Feature | Trintellix | SSRIs (e.g., Lexapro) | SNRIs (e.g., Cymbalta) |
|---|---|---|---|
| Mechanism | Multimodal (SERT + receptors) | Pure SERT inhibition | SERT + NET inhibition |
| Cognition | Pro-cognitive | Neutral/negative | Variable |
| Sexual SEs | Low risk | High risk | Moderate risk |
| Weight | Neutral | Gain (common) | Gain (possible) |
Patient Considerations
Nausea Management: Take with food, start at 5mg, or use ginger supplements.
Elderly: No dose adjustment needed (unlike many antidepressants).
Pregnancy (Category C): Limited data – weigh risks vs. benefits.
Storage & Handling
Room temperature (15–30°C).
Protect from moisture.
Final Notes
Trintellix is ideal for depressed patients with cognitive complaints or those intolerant to SSRI sexual side effects. Its unique pharmacology justifies premium pricing, though cost may limit access.
Disclaimer: Trintellix is prescription-only. Abrupt discontinuation may cause withdrawal (taper over weeks).
Additional information
| Dosage | 5mg, 10mg, 15mg, 20mg |
|---|---|
| Quantity | 60 Tabs, 90 Tabs |
Reviews
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