Remeron (Mirtazapine)
€117.00 – €280.00
Description
Remeron (Mirtazapine)
Remeron (mirtazapine) is a tetracyclic antidepressant (TeCA) with a unique dual mechanism as a noradrenergic and specific serotonergic antidepressant (NaSSA). It is widely prescribed for major depressive disorder (MDD) and is particularly valued for its sedative, appetite-stimulating, and anti-nausea effects, making it ideal for patients with insomnia, weight loss, or SSRI-induced nausea.Buy Remeron (Mirtazapine) online
Key Features & Benefits
✔ Rapid Sleep Improvement – Strong H1 histamine blockade induces sedation (especially at lower doses).Buy Remeron (Mirtazapine) online
✔ Appetite Stimulation – Effective for cachexia, anorexia, or depression-related weight loss.
✔ Minimal Sexual Dysfunction – Unlike SSRIs, it rarely causes libido/orgasm issues.
✔ Anti-Emetic – 5-HT3 antagonism reduces nausea (useful in chemotherapy adjunct therapy).
✔ Low Cardiac Risk – No significant QT prolongation.
Dosage & Administration
Available Forms: 7.5mg, 15mg, 30mg, 45mg tablets/orally disintegrating tabs (SolTab).
Starting Dose: 7.5–15mg at bedtime (lower doses = more sedation).
Therapeutic Range: 15–45mg/day (higher doses = more noradrenergic effects, less sedation).
Titration: Increase by 15mg every 1–2 weeks.
Mechanism of Action
| Receptor | Effect | Clinical Impact |
|---|---|---|
| α2-Adrenergic Antagonist | ↑ Noradrenaline & serotonin release | Antidepressant, energizing (at higher doses) |
| 5-HT2A/2C Antagonist | Prevents serotonin-mediated anxiety/insomnia | Calming, improves sleep |
| H1 Antagonist | Strong sedative & appetite stimulant | Weight gain, drowsiness |
| 5-HT3 Antagonist | Reduces nausea/vomiting | Useful in chemo/SSRI-induced nausea |
Side Effects
⚠ Common:
Weight gain (5–10+ lbs, dose-dependent)
Sedation (most pronounced at 7.5–15mg)
Dry mouth, dizziness
⚠ Rare but Serious:Agranulocytosis (very rare; monitor WBC if fever/sore throat occurs)
Hyponatremia (elderly at risk)
Contraindications
MAOI use (risk of serotonin syndrome).
Severe liver/kidney impairment (dose adjustment needed).
History of neutropenia.
Comparison to Other Antidepressants
| Feature | Remeron (NaSSA) | SSRIs (e.g., Prozac) | TCAs (e.g., Amitriptyline) |
|---|---|---|---|
| Sedation | High (low dose) | Mild | Very high |
| Weight Effect | Significant gain | Neutral/gain | Gain |
| Sexual SEs | Rare | Common | Moderate |
| Cardiac Risk | Low | Low | High (QTc prolongation) |
Special Populations
Elderly: Start at 7.5mg (↑ fall risk due to sedation).
Cancer/Cachexia Patients: Ideal for appetite stimulation.
Pregnancy (Category C): Limited data; use if benefits outweigh risks.
Storage & Handling
Room temperature (protect from moisture).
SolTabs: Keep blister pack sealed until use.
Final Notes
Remeron is a first-choice antidepressant for patients with insomnia, poor appetite, or SSRI intolerance. Its unique pharmacology allows for flexible dosing (sedation at low doses, energizing at higher doses).
Disclaimer: Abrupt discontinuation may cause withdrawal (taper slowly).
Additional information
| Dosage | 7.5mg, 15mg, 30mg, 45mg |
|---|---|
| Quantity | 60 Tabs, 90 Tabs |
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