Description

Prozac (Fluoxetine)

Prozac (fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) and one of the most widely prescribed antidepressants worldwide. It is FDA-approved for major depressive disorder (MDD), obsessive-compulsive disorder (OCD), bulimia nervosa, and panic disorder, with additional off-label uses in PMDD, PTSD, and binge eating disorder.Buy Prozac (Fluoxetine) online

Key Features & Benefits

✔ Long Half-Life (2–4 days) – Allows once-daily dosing and smoother withdrawal.Buy Prozac (Fluoxetine) online
✔ Activating Effect – Often preferred for depression with fatigue/low motivation.
✔ FDA-Approved for Pediatric OCD (ages 7+).
✔ Low Cardiovascular Risk – Unlike TCAs, no QTc prolongation.

Dosage & Forms

• Capsules: 10mg, 20mg, 40mg.

• Tablets: 60mg (for weekly dosing in maintenance).

• Liquid: 20mg/5mL.

• Typical Starting Dose: 20mg/day AM (lower for anxiety/panic).

• Max Dose: 80mg/day (for OCD).

Mechanism of Action

• Potent SERT Inhibition – Blocks serotonin reuptake, increasing synaptic 5-HT.

• Weak 5-HT2C Antagonism – May contribute to lower appetite suppression vs. other SSRIs.

Side Effects

⚠ Common (Early):

• Insomnia, nausea, headache (often transient).

• Anxiety/agitation (start low in panic disorder).
  ⚠ Late/Persistent:

• Sexual dysfunction (↓ libido, anorgasmia – up to 50%).

• Weight gain (long-term).

Serious Risks

• Suicidal Ideation (↑ in adolescents; monitor closely).

• Serotonin Syndrome (if combined with MAOIs/other serotonergics).

• Bleeding Risk (caution with NSAIDs/warfarin).

Contraindications

• MAOI use (wait 5 weeks after stopping Prozac).

• Uncontrolled epilepsy.

• Concomitant pimozide/thioridazine (QT risk).

Comparison to Other SSRIs

Special Populations

• Pediatrics: Only SSRI approved for OCD (ages 7+) and MDD (ages 8+).

• Pregnancy (Category C): Potential neonatal withdrawal; consider risks vs. benefits.

• Elderly: Reduce dose (↑ half-life).

Unique Advantages

• Weekly Form (Prozac Weekly™ 90mg) for maintenance.

• Preferred in Bulimia (reduces binge-purge cycles).

• Less Tapering Needed due to long half-life.

Storage & Handling

• Room temperature (avoid moisture).

• Liquid: Protect from light.

Final Notes

Prozac remains a first-line SSRI for depression with fatigue, OCD, and bulimia, but its activating effects and sexual SEs may limit tolerability for some.

Disclaimer: *Full effects take 4–6 weeks. Abrupt stoppage is safer vs. short-acting SSRIs but taper advised.*