Description

Cymbalta (Duloxetine) 

Cymbalta (duloxetine) is a serotonin-norepinephrine reuptake inhibitor (SNRI) approved for major depressive disorder (MDD), generalized anxiety disorder (GAD), diabetic peripheral neuropathy (DPN), fibromyalgia, and chronic musculoskeletal pain. Its dual neurotransmitter modulation makes it unique among antidepressants, offering both mood stabilization and pain relief.Buy Cymbalta (Duloxetine) online

Key Features & Benefits

✔ Dual-Action Antidepressant – Increases serotonin (5-HT) and norepinephrine (NE) for balanced mood and energy.Buy Cymbalta (Duloxetine) online
✔ FDA-Approved for Chronic Pain – Effective for neuropathic pain, fibromyalgia, and osteoarthritis.
✔ Anxiolytic Properties – Reduces both emotional and physical symptoms of anxiety.
✔ Delayed-Release Capsules – Minimizes GI side effects with once-daily dosing.

Dosage & Administration

• Available Strengths: 20mg, 30mg, 60mg capsules.

• Starting Dose: 30mg/day (for depression/anxiety) or 60mg/day (for pain).

• Therapeutic Range: 60mg/day (most common), up to 120mg/day (rare, for severe cases).

• Administration: Swallow whole with or without food (avoid crushing/chewing).

Mechanism of Action

Side Effects

⚠ Common (≥10%):

• Nausea (improves after 1–2 weeks)

• Dry mouth, fatigue, constipation

• Increased sweating
  ⚠ Serious (Rare):

• Liver toxicity (monitor ALT/AST if high-risk)

• Hypertension (check BP regularly)

• Serotonin syndrome (if combined with MAOIs)

Withdrawal & Discontinuation

• Half-Life: ~12 hours → moderate withdrawal risk.

• Tapering Protocol:

  • Reduce by 30mg every 1–2 weeks.

  • Avoid abrupt stoppage (risk of dizziness, “brain zaps”).

Contraindications

• MAOI use (wait 14 days before/after Cymbalta).

• Uncontrolled narrow-angle glaucoma.

• Severe liver/kidney disease (avoid in cirrhosis).

• Pregnancy (Category C) – Potential neonatal complications.

Comparison to Other SNRIs

Special Populations

• Elderly: Start at 20–30mg/day (↑ sensitivity to side effects).

• Hepatic Impairment: Max 60mg/day (avoid if severe).

• Chronic Pain Patients: Often see pain relief before mood improvement.

Storage & Handling

• Room temperature (15–30°C).

• Keep capsules dry (do not split).

Final Notes

Cymbalta is a first-line choice for depression with comorbid pain or anxiety, but its GI side effects and withdrawal risk require careful management.

Disclaimer: Cymbalta is prescription-only. Taper slowly to avoid withdrawal.