Description

Celexa (Citalopram) 

Celexa (citalopram) is a selective serotonin reuptake inhibitor (SSRI) prescribed for major depressive disorder (MDD) and off-label for anxiety disorders. Known for its clean pharmacological profile, Celexa is often chosen as a first-line antidepressant due to its efficacy, tolerability, and lower drug interaction risk compared to other SSRIs.Buy Celexa (Citalopram) online

Key Features & Benefits

✔ Highly Selective Serotonin Reuptake Inhibition – Minimal impact on dopamine/norepinephrine.Buy Celexa (Citalopram) online
✔ Low Side Effect Profile – Fewer drug interactions than fluoxetine/paroxetine.
✔ FDA-Approved for Depression – Effective for moderate to severe MDD.
✔ Off-Label Uses: Generalized anxiety disorder (GAD), panic disorder, OCD.

Dosage & Administration

• Available Strengths: 10mg, 20mg, 40mg tablets; 10mg/5mL oral solution.

• Starting Dose: 20mg once daily (AM or PM).

• Max Dose: 40mg/day (20mg/day for elderly or hepatic impairment).

• FDA Warning: Do not exceed 40mg/day (risk of QT prolongation).

Mechanism of Action

• Potent SERT Inhibition – Blocks serotonin reuptake, increasing synaptic 5-HT levels.

• Minimal Receptor Affinity – Unlike some SSRIs, it has negligible anticholinergic or histaminergic effects, reducing sedation/weight gain.

Side Effects

⚠ Common (≥10%):

• Nausea (usually transient)

• Dry mouth, drowsiness, sweating

• Sexual dysfunction (↓ libido, delayed orgasm – ~30% of users)
  ⚠ Serious (Rare):

• QT Prolongation (dose-dependent; avoid in heart disease)

• Serotonin Syndrome (if combined with MAOIs/other serotonergics)

• Hyponatremia (elderly at higher risk)

Contraindications

• MAOI use (wait 14 days between).

• Congenital long QT syndrome/heart disease (due to arrhythmia risk).

• Pregnancy (Category C) – Potential neonatal complications.

Comparison to Other SSRIs

Special Populations

• Elderly: Max 20mg/day (↑ QT/sodium imbalance risk).

• Hepatic Impairment: Reduce dose by 50%.

• Pediatrics: Not FDA-approved for <18 years (↑ suicide risk).

Storage & Handling

• Room temperature (15–30°C).

• Oral solution: Protect from light.

Final Notes

Celexa is a well-tolerated SSRI ideal for first-time antidepressant users or those needing minimal drug interactions. However, its QT prolongation risk at high doses requires caution in cardiac patients.

Disclaimer: Full effects take 4–6 weeks. Taper gradually to avoid withdrawal.