Description

Compazine® (Prochlorperazine) 5mg – Prescription Antipsychotic & Antiemetic

Compazine® (prochlorperazine) is a first-generation antipsychotic (phenothiazine class) primarily used to treat:Buy Compazine 5mg online
✔ Severe nausea/vomiting (including chemotherapy-induced)
✔ Anxiety/short-term psychosis (off-label)
✔ Migraine-associated nausea

Available as 5mg tablets, suppositories, and injectable solutions.

Key Features

• Strong Dopamine (D2) Blocker – Also affects histamine/cholinergic receptors.Buy Compazine 5mg online
• Sedating Effect – Can cause drowsiness
• Non-Addictive – Unlike benzodiazepines
• Hospital & Outpatient Use

FDA-Approved Uses

• Severe nausea/vomiting (post-op, chemotherapy, gastroenteritis)
• Schizophrenia (less commonly today due to newer antipsychotics)

Dosage Guidelines

For Nausea/Vomiting (Adults):

• Oral: 5–10mg 3–4x daily (max 40mg/day)

• Rectal (suppository): 25mg 2x daily

• IM/IV (severe cases): 5–10mg every 3–4h (max 40mg/day)

For Psychosis/Agitation:

• 10mg 3–4x daily (oral/IM)

⚠ Elderly Patients: Start with lower doses (higher risk of side effects)

Serious Risks & Side Effects

⚠ Extrapyramidal Symptoms (EPS):

• Dystonia (muscle spasms)

• Akathisia (restlessness)

• Parkinsonism (tremors)

• Tardive dyskinesia (long-term use)

⚠ Neuroleptic Malignant Syndrome (NMS) – Life-threatening fever/rigidity
⚠ QT Prolongation – Risk of dangerous heart rhythms
⚠ Anticholinergic Effects: Dry mouth, blurred vision, constipation

Common Side Effects:

• Drowsiness

• Dizziness

• Low blood pressure

Black Box Warnings (FDA)

1. Increased Mortality in Elderly Dementia Patients (not approved for this use)

2. Tardive Dyskinesia (potentially irreversible)

Drug Interactions

❌ CNS Depressants (alcohol, opioids, benzodiazepines) – Enhanced sedation
❌ QT-Prolonging Drugs (amiodarone, fluoroquinolones) – Arrhythmia risk
❌ Anticholinergics (Benadryl) – Worsens side effects

Who Should NOT Take Compazine?

✖ Parkinson’s disease (worsens symptoms)
✖ Severe heart disease (QT prolongation risk)
✖ Glaucoma (increased eye pressure)
✖ Seizure disorders (lowers seizure threshold)

Storage & Handling

• Tablets: Room temperature (15–30°C)

• Suppositories: Refrigerate

• Protect from light

Safe Use Guidelines

✅ Stay hydrated (prevents low blood pressure)
✅ Avoid driving until effects are known
✅ Monitor for EPS symptoms (report muscle spasms immediately)

Why Choose Compazine?

When strong antiemetic effects are needed without opioid use, Compazine offers:
• Rapid relief (especially IV/IM)
• Non-narcotic option
• Low abuse potential

Warning: Not for mild nausea (use OTC options first).

Use the lowest effective dose for the shortest duration.

For EPS symptoms: Diphenhydramine (Benadryl) or benztropine may be prescribed.