Description

Paxil (Paroxetine)

Paxil (paroxetine) is a potent selective serotonin reuptake inhibitor (SSRI) primarily prescribed for major depressive disorder (MDD), generalized anxiety disorder (GAD), panic disorder, social anxiety disorder (SAD), and obsessive-compulsive disorder (OCD). Known for its strong anxiolytic effects, Paxil is often favored for anxiety-related conditions but carries a higher risk of withdrawal symptoms and sedation compared to other SSRIs.Buy Paxil (Paroxetine) online

Key Features & Benefits

✔ Highly Anxiolytic – Especially effective for GAD, panic attacks, and social phobia.Buy Paxil (Paroxetine) online
✔ Sedating at Low Doses – Useful for depression with insomnia or agitation.
✔ Multiple Formulations – Immediate-release (IR) and controlled-release (CR) versions available.
✔ FDA-Approved for PTSD – One of the few SSRIs with this indication.

Dosage & Administration

• IR Tablets: 10mg, 20mg, 30mg, 40mg.Buy Paxil (Paroxetine) online

• CR Tablets (Paxil CR): 12.5mg, 25mg, 37.5mg.

• Starting Dose:

  • Depression/Anxiety: 10–20mg/day (AM or PM).

  • Panic Disorder: 10mg/day (start low to avoid worsening anxiety).

• Max Dose: 50–60mg/day (IR), 62.5mg/day (CR).

Mechanism of Action

• Strong SERT Inhibition – Highly selective for serotonin reuptake blockade.

• Weak Anticholinergic Effects – Contributes to sedation and dry mouth.

• Minimal Dopamine/Norepinephrine Activity – Unlike SNRIs.

Side Effects

⚠ Common:

• Fatigue/sedation (dose-dependent).

• Sexual dysfunction (higher incidence vs. other SSRIs).

• Weight gain (long-term use).

• Nausea (usually transient).
  ⚠ Serious but Rare:

• Suicidal ideation (especially in young adults).

• Serotonin syndrome (with MAOIs/other serotonergics).

• Withdrawal syndrome (due to short half-life).

Withdrawal & Discontinuation

• Half-Life: ~24 hours (shorter than Prozac, leading to faster withdrawal).

• Symptoms: Dizziness, “brain zaps,” nausea, irritability.

• Tapering Required: Reduce by 10mg every 1–2 weeks (consider switching to fluoxetine for easier discontinuation).

Contraindications

• MAOI use (risk of serotonin syndrome – wait 14 days between).

• Pregnancy (Category D) – Linked to cardiac malformations (avoid if possible).

• Glaucoma (due to mild anticholinergic effects).

Comparison to Other SSRIs

Special Populations

• Elderly: Start at 5–10mg/day (↑ sensitivity to side effects).

• Children/Teens: Not FDA-approved for pediatric depression (↑ suicide risk).

• Hepatic Impairment: Lower doses needed.

Storage & Handling

• Room temperature (avoid moisture).

• CR Tablets: Swallow whole (do not crush/chew).

Final Notes

Paxil is a highly effective SSRI for anxiety disorders but is less favored for long-term use due to withdrawal challenges, sexual dysfunction, and weight gain. It remains a first-line option for severe GAD or panic disorder when tolerability is manageable.

Disclaimer: Paxil requires gradual tapering. Avoid abrupt discontinuation.