Description

Demerol® (Meperidine HCl) – Official Product Description

Brand Name: Demerol®.Buy Demerol online
Generic Name: Meperidine Hydrochloride
Drug Class: Opioid Analgesic (Schedule II Controlled Substance)

Product Overview

Demerol is a synthetic opioid analgesic used for the short-term management of moderate to severe pain. It acts primarily on the central nervous system (CNS) to provide pain relief but carries a high risk of dependence, abuse, and serious side effects, including respiratory depression.Buy Demerol online

Available 
✅ Injection (IV/IM/SC):  50mg/mL

FDA-Approved Uses

1. Acute Pain Management (post-surgical, trauma, severe injury)

2. Pre-Anesthetic Sedation (before surgical procedures)

3. Obstetric Analgesia (labor pain, under strict medical supervision)

⚠ Not Recommended for Chronic Pain – Due to toxic metabolite (normeperidine) buildup, which can cause seizures.

Mechanism of Action

• Mu-opioid receptor agonist → Blocks pain signals in the brain and spinal cord.

• Weak serotonin reuptake inhibitor → May contribute to analgesic effects.

• Produces euphoria and sedation → High potential for abuse and addiction.

Dosage & Administration

Duration of Effect:

• Oral/IM: 2–4 hours

• IV: 1–2 hours

Side Effects

🔹 Common:

• Drowsiness, dizziness, nausea/vomiting

• Constipation, sweating, dry mouth

• Euphoria (can lead to psychological dependence)

🔹 Serious (Seek Immediate Help):

• Respiratory depression (slow/shallow breathing)

• Hypotension (low blood pressure)

• Seizures (from normeperidine toxicity with long-term use)

• Serotonin syndrome (if combined with SSRIs/MAOIs)

Black Box Warnings

🚩 High Potential for Addiction & Abuse (Schedule II Controlled Substance)
🚩 Life-Threatening Respiratory Depression (especially with alcohol/benzodiazepines)
🚩 Accidental Ingestion Can Be Fatal (keep away from children)

Contraindications

❌ MAOI use (or within 14 days) → Fatal serotonin syndrome risk
❌ Severe asthma/COPD (respiratory failure risk)
❌ Head injury/ICP (can worsen sedation & breathing)
❌ GI obstruction (opioids slow digestion)

Drug Interactions

• Benzodiazepines/Alcohol → Deadly respiratory depression

• SSRIs/SNRIs → Serotonin syndrome risk

• CYP3A4 inhibitors (e.g., ketoconazole) → Increased toxicity

Storage & Safety

✅ Store at 20–25°C (68–77°F)
✅ Keep in a locked container (prevents misuse/theft)
✅ Dispose of unused medication properly (DEA take-back programs)

Alternatives for Pain Management

• Non-Opioid Options: NSAIDs (ibuprofen), acetaminophen, gabapentin

• Safer Opioids: Oxycodone (short-term), buprenorphine (lower abuse risk)

Prescription Required – No OTC Availability

For use only under strict medical supervision.